Over 20 years ago, the psychiatrist Egon Haberfellner attempted to
recruit patients for a planned clinical trial of antidepressant
medication from his community practice. He discovered that only one
of the 216 patients with depression that he treated over a 6-month
period in his clinic was eligible to participate. As a diplomatic
understatement, he concluded that "study results obtained under
restrictive inclusion and exclusion criteria are probably only
applicable to a proportion of patients treated under routine conditions".
http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30512-6/fulltext
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